Signal Transduction in Cancer

Turin, Italy •
22-24 November 2018

Programme

  • Thursday, 22 November

    14:30

    Registration
    From basic research to target therapy

    Chair: Barbara Belletti

    16:00-16:50

    Plenary Lecture

    Emilio Hirsch (Turin)
    Scaffold function of PI3Ks in cancer and cystic fibrosis

    Selected talks
    16:50-17:10 Giulia Petroni (Florence)
    Exploiting hERG1-mediated autophagy for overcoming chemotherapy resistance in colorectal cancer
    17:10-17:30 Lorena Quirico (Turin)
    Axl-148b chimeric aptamers inhibit melanoma and breast cancer progression
    17:30-17:50 Ilenia Pellarin (Aviano)
    Splicing Factor Proline and Glutamine rich (SFPQ) protein regulates platinum response in epithelial ovarian cancer
    17:50-18:10 Alessandro Giammona (Montpellier, France)
    Stapled peptides as inhibitors of PXR: an alternative therapeutic strategy for sensitizing cancer cell and stem cells to chemotherapy

    18:10-20:00

    "Aperitivo" and Poster Session I

  • Friday, 23 November
    Signaling pathways in migration and invasion: from cells to human cancer

    Chair: Guido Serini

    9:00-9:50

    Plenary Lecture

    Jim Norman (Glasgow, UK)
    The nuclear import machinery captures endosomes to drive depletion of nuclear G-actin, SRF/MRTF gene expression and invasive behaviour in cancer

    Selected talks
    9:50-10:10 Federica Fusella (Turin)
    The IKK/ NF-κB signalling pathway requires morgana to drive breast cancer metastasis
    10:10-10:30 Donatella Valdembri (Turin)
    Decoding endothelial cell polarity: how PPFIA1 coordinates Golgi secretion and adhesion site turnover

    10:30-11:00

    Coffee break
    Signaling pathways in migration and invasion: from cells to human cancer

    Chair: Giulia Piaggio

    11:00-11:40

    Plenary Lecture

    Enzo Medico (Candiolo, TO)
    In vivo cancer modeling with patient-derived xenografts: challenges and opportunities

    Selected talks
    11:40-12:00 Irene Schiano Lomoriello (Milan)
    The endocytic protein Epsin3 drives EMT and cancer stem cell expansion in breast cancer
    12:00-12:20 Andreja Ambriovic-Ristov (Zagreb, Croatia)
    Characterisation of integrin αV-dependent adhesome in melanoma cell line MDA-MB-435S

    12:20-14:30

    Lunch and Poster Session II
    Signaling circuitries in tumor microenvironment

    Chair: Daniela Taverna

    14:30-15:20

    Plenary Lecture

    Massimiliano Mazzone (Leuven, Belgium)
    Podoplanin-expressing macrophages: a "PoEM" on breast cancer metastasis

    Selected talks
    15:20-15:40 Valeria Poli (Turin)
    STAT3 target genes mediate the cross-talk between cancer associated fibroblasts and cancer cells
    15:40-16:00 Vincenzo Salemme (Turin)
    p140Cap affects breast cancer features through the regulation of the tumor microenvironment composition
    16:00-16:20 Francesca Orso (Turin)
    miR-214 in tumor-stroma cell interactions
    16:20-16:40 Raffaele Strippoli (Rome)
    HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal

    16:40-17:10

    Coffee break
    Signaling circuitries in tumor microenvironment

    Chair: Letizia Lanzetti

    Selected talks
    17:10-17:30 Gianluca Mucciolo (Turin)
    IL17 depletion as a strategy to shape the pancreatic tumor microenvironment and enhance the efficacy of alpha-enolase vaccination
    17:30-17:50 Manpreet Patheja (Naples)
    Shp1 domains involved in the direct binding of glycerophosphoinositols
    17:50-18:10 Annamaria Antona (Novara)
    Spiperone, an antipsychotic, induces colorectal carcinoma cell death by a calcium-mediated apoptosis
    18:10-18:30 Francesca Corsi (Rome)
    Therapy-induced cancer repopulation and acquired chemoresistance (CRAC): a simple in vitro model of phoenix rising in prostate cancer
    18:30-18:50 Cecilia Battistelli (Rome)
    Deciphering molecular mechanisms driving EMT

    20:00

    Social Dinner (only for attendies who signed up for this option)

  • Saturday, 24 November
    Signaling-metabolic rewiring in cancer

    Chair: Paolo Ettore Porporato

    9:00-9:50

    Plenary Lecture

    Carlos Sebastiàn (Candiolo, TO)
    SIRT6-dependent metabolic reprogramming as a driver of stem cell fate and tumorigenesis

    Selected talks
    9:50-10:10 Daniele Avanzato (Turin)
    High USP6NL levels in breast cancer sustain chronic AKT phosphorylation and GLUT1 stability fueling aerobic glycolysis
    10:10-10:30 Andrea Morandi (Florence)
    Amino acids availability and subsequent metabolic reprogramming sustain endocrine therapy resistance in estrogen receptor positive breast cancer

    10:30-11:00

    Coffee break

    Selected talks
    11:00-11:20 Miriam Martini (Turin)
    Loss of PI3K-C2G promotes pancreatic cancer through mTOR regulation and metabolic rewiring
    11:20-11:40 Veronica Fiorito (Turin)
    The heme exporter FLVCR1a modulates the tricarboxylic acid cycle: a new target in colorectal cancer
    11:40-12:00 Giulia Dell’Omo (Milan)
    Inhibition of SIRT1 deacetylase and p53 activation uncouples the anti-inflammatory and chemopreventive actions of NSAIDs
    12:00-12:20 Chiara Di Malta (Pozzuoli, NA)
    Transcriptional regulation of mTORC1 promotes cancer growth

    12:20-12:30

    Concluding remarks

  • The poster's maximum size is A0 (841 x 1189 mm; width x height).

    Correct format... poster should be PORTRAIT  poster should NOT be LANDSCAPE Wrong format...

     

    Posters will be on display for the entire duration of the meeting. Posters with an even number will be presented during Poster Session I (Thursday, 22 November). Posters with an odd number will be presented during Poster Session II (Friday, 23 October).

    List of Posters

    P.1  Silvia Albertini (Turin)
    The impact of cancer associated fibroblasts (CAFs) on Merkel cell carcinoma progression

    P.2  Elia Angelino (Milan)
    Pro-cachectic cytokines TNFα and IFNγ perturb the adrenergic signaling in myoblasts

    P.3  Lidia Avalle (Turin)
    The pro-oncogenic transcription factor STAT3 regulates Ca2+ release and apoptosis from the Endoplasmic Reticulum via interaction with the Ca2+ channel IP3R3

    P.4  Gianluca Baldanzi (Novara)
    Identification of a novel DGKα inhibitor for XLP-1 therapy by virtual screening

    P.5  Jennifer Chapelle (Turin)
    The p140Cap adaptor protein acts as a molecular hub that negatively control signaling through association with specific partners in breast cancer cells

    P.6  Francesca Chiarini (Bologna)
    Exploring the role of the nuclear protein lamin A/C in osteoblasts and osteosarcoma cells

    P.7  Andrea Costamagna (Turin)
    Conditional ablation of p130Cas/BCAR1 adaptor protein impairs epidermal homeostasis by altering cell adhesion and differentiation

    P.8  Abhishek Derle (Turin)
    Role of PI3KC2A in modulating the glucose homeostasis

    P.9  Camilla Evangelisti (Bologna)
    Targeting Wnt/b-catenin and PI3K pathways in T-cell acute lymphoblastic leukemia

    P.10  Giovanni Giangreco (Milan)
    Epsin3 induces a partial EMT state in breast cancer through the regulation of E-Cadherin endocytosis

    P.11  Myriam Hsu (Turin)
    Altered iron metabolism promotes cancer cachexia

    P.12  Annamaria Massa (Turin)
    miR-214 in tumor-stroma cell interactions

    P.13  Chiara Mauro (Milan)
    DGKα in the regulation of TCR-induced cell death: role of cytoskeleton and actin polymerization

    P.14  Giorgia Mungo (Aviano)
    Loss of p27kip1 promotes Δ16HER2-induced breast cancer

    P.15  Sara Petrillo (Turin)
    Modulation of cytosolic heme to control metabolism and survival of tumor endothelial cells

    P.16  Emanuela Pupo (Turin)
    RabGAP proteins as target of derailed metabolism in triple negative breast cancer

    P.17  Pranoy Sahu (Naples)
    Identification  and characterization of a Golgi glycosyltransferase as a new potential oncogene

    P.18  Laura Seclì (Turin)
    The pro-migratory function of extracellular morgana in triple negative breast cancer cells

    P.19  Navid Sobhani (Trieste)
    Correlation between molecular oncology, immune profile, therapeutic markers, and signatures with the clinical outcome in human tumours

    P.20  Daniela Taverna (Turin)
    miR-214 in tumor-stroma cell interaction

    P.21  Elisabeth Wyart (Turin)
    Metabolic alterations in a slow-paced model of pancreatic cancer-induced wasting